FMC7 (CD20) Antigen
FMC7 is a transmembrane glycoprotein with a molecular weight of 105 kDa. This antigen was described as a particular conformation of a surface protein encoded by the CD20 gene. FMC7 antibody reactivity to its particular CD20 epitope was found to be dependent of membrane cholesterol level. In circulating blood cells, FMC7 is expressed by a B lymphocyte subpopulation. It is not detected on T lymphocytes, NK cells, polymorphonuclear granulocytes, platelets, nor on erythrocytes. The subpopulation of B lymphocytes expressing the FMC7 antigen expresses surface immunoglobulins, thus defining a stage of maturation of the B lymphocytes distinct from FMC7– B lymphocytes.
|Clone: FMC7||Isotype: IgM Mouse|
|The FMC7 antibody reacts with a subpopulation of peripheral blood B lymphocytes and tonsil B cells, but it does not react with granulocytes, monocytes, platelets, erythrocytes, T lymphocytes or null cells.|
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Product Line Specifications
|Flow Product Line||IOTest|
|Item Specifications Referenced||IM1364U|
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.