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The CD62P antigen (P-selectin/GMP-140/PADGEM) is a member of the selectin family. Like other selectins (CD62E and CD62L), CD62P contains an amino terminal lectin-like domain, followed by an EGF domain, nine short consensus repeats (SCR), a transmembrane domain and a short cytoplasmic domain. CD62P (140 kDa) is present in megakaryocytes, in Weibel-Palade bodies of endothelial cells and in α-granules of platelets. CD62P is translocated to the surface membrane upon in vitro and in vivo activation. CD62P is involved in the interaction between activated platelets and with monocytes and neutrophils.
Isotype: IgG1 Mouse
The CLB-Thromb/6 antibody recognizes the boundary region between the lectin and EGF-like domains, which is preserved after platelet fixation. It inhibits platelet adhesion to eosinophils in cell adhesion assays.
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.
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